egf receptor การใช้

• Src is activated by the EGF receptor family ligand Neuregulin.
• In addition, another batch of drugs target the similarly-functioning EGF receptors.
• Researchers are testing antibodies, similar to Herceptin, that block the EGF receptor.
• Rhomboids were first discovered as proteases that regulate EGF receptor signalling in " Drosophila ".
• In some cancers, cells have many extra copies of the EGF receptor, so the growth message gets vastly amplified.
• It can also phosphorylate components in the upstream portion of the MAPK signalling cascade including Ras, Sos, and the EGF receptor itself.
• Altogether these studies provided much of the framework that ultimately led to the use of antibodies targeted to the EGF receptor as a cancer therapy.
• The radiation damages the cell while the C225 antibody blocks a chemical growth factor, the EGF receptor, that the cell needs in order to divide.
• HB-EGF binding and activation of EGF receptors plays a critical role during cardiac valve tissue development and the maintenance of normal heart function in adults.
• Following the identification of the EGF receptor by Stanley Cohen, Pastan and colleagues made several seminal advances that identified the EGF receptor as a proto-oncogene.
• Following the identification of the EGF receptor by Stanley Cohen, Pastan and colleagues made several seminal advances that identified the EGF receptor as a proto-oncogene.
• During valve tissue development the interaction of HB-EGF with EGF receptors and heparan sulfate proteogylcans is essential for the prevention of malformation of valves due to enlargement.
• The mitotic trigger, polarization in budding EGF receptor signaling, platelet activation, and Xenopus oocyte maturation are examples for interlinked fast and slow multiple positive feedback systems.
• CRM197 possess a binding site for EGF receptor heparin-binding epidermal growth factor-like growth factor ( HB-EGF ), a member of the EGF family.
• NEDD4 mediates ubiquitination and subsequent down-regulation of components of the epidermal growth factor ( EGF ) signalling pathway, such as HER3 and HER4 EGF receptors, and ACK.
• Such efforts have been successful at reducing EGF receptor expression, its downstream signaling, and consequently malignant behavior of the cancer cell such as migration, invasion, and cell detachment.
• Functional interactions with the EGF receptor and the type I / type II TGF? receptor system have also been reported, and other cell-surface proteins such as proteoglycans also bind IGFBP-3.
• Genetic analysis later proved that this group of genes were members of the epidermal growth factor ( EGF ) receptor signalling pathway, and that rhomboid was needed to generate the signal that activates the EGF receptor.
• Interestingly, in the mouse, iRhoms are key trafficking chaperones required for the ER export of ADAM17 / TACE and its maturation . iRhoms are thus required for the TNF-alpha and EGF receptor signalling, making them medically highly attractive.
• Lipid rafts have been found by researchers to be involved in many signal transduction processes, such as Immunoglobulin E signalling, T cell antigen receptor signalling, B cell antigen receptor signalling, EGF receptor signalling, insulin receptor signalling and so on.